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TCGA's Study of Paraganglioma & Pheochromocytoma

About a third of all cancers are driven by mutations in RAS genes. Learn how NCI funding is helping Dr. Kevan Shokat develop drugs that inactivate molecular drivers of cancer such as RAS.

While standard biological methods such as two-dimensional, in vitro cell culture and in vivo animal models are useful to examine certain biological questions, the complexity of cancer requires a continuum of model systems. This collaborative study will create a foundation for tumor tissue engineering by employing multiple innovative methodologies to first characterize and then build biomimetic models of the extracellular matrix (ECM) in the tumor microenvironment. The ECM is a key element in biomimicry, and particularly important to consider in the context of cancer, where the composition and architecture of the ECM change drastically with disease progression.

Read how melanoma survivor T.J. Sharpe’s experience on two clinical trials highlights the need for biomarkers to predict benefit from immunotherapy.

Using TCGA in your research? Learn about the data and other resources available.

Chordoma is a slow growing cancer of tissue found inside the spine, formed from the left-over cells that were important in the development of the spine before birth. Learn more about chrodomas, how they are diagnosed, and how they are treated.

This list of publications from the RAS Initiative reflects the balance between the public responsibilities of the National Cancer Institute and the requirements of our external partners.

Carryover is the process by which unobligated funds remaining at the end of a budget period may be carried forward to cover allowable costs in the next budget period. Learn more about how to carryover NCI grants.

Mentorship is an important part of the trainee experience at NCI and NIH. Learn how to choose and find mentors and how to get involved in mentoring others.

Fellows and cancer research trainees will find information to support their onboarding at NCI, including stipend and tax information and NIH rules and regulations. Learn more about orientation for NCI trainees.