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If you have a known family history of Marfan syndrome or physical features of the condition, your doctor may recommend screening to find the condition early. Relatives of people who have Marfan syndrome may also want to have genetic screening. There is no way to prevent Marfan syndrome.

Sleep apnea can be caused by a person’s physical structure or medical conditions. These include obesity, large tonsils, endocrine disorders, neuromuscular disorders, heart or kidney failure, certain genetic syndromes, and premature birth.

Heart conditions and other disorders, age-related changes, rheumatic fever, or infections can cause acquired heart valve disease. These factors change the shape or flexibility of once-normal heart valves. The cause of congenital heart valve disease isn't know.

Many people who have peripheral artery disease do not have any signs or symptoms. When people do have signs and symptoms of peripheral artery disease, they can include intermittent claudication, weak or absent pulses in the legs or feet, sore or wounds on the toes, feet, or legs that heal slowly, a pale or bluish color to the skin, a lower temperature in one leg compared to the other leg, poor nail growth, and erectile dysfunction.

Mitral valve prolapse is a condition in which the flaps of the mitral valve are floppy, or prolapsed, which can prevent the seal from forming, which results in a backflow of blood in the left atrium as blood is pumped through the heart.

People at greatest risk for metabolic syndrome have high abdominal obesity, an inactive lifestyle, and insulin resistance. Some racial and ethnic groups in the United States are at higher risk for metabolic syndrome than others.

The most common cause of peripheral artery disease is atherosclerosis, which may develop when certain factors damage the inner layers of the arteries. The buildup of plaque can severely narrow or block arteries, which limits the flow of oxygen-rich blood to your organs and other parts of your body.

Controlling certain risk factors by staying physically active, following a heart-healthy eating plan, quitting smoking, and losing weight if you’re overweight or obese can help prevent or delay peripheral artery disease and its complications. By following these recommendations, you can also prevent and control other conditions associated with peripheral artery disease, such as coronary heart disease, diabetes, high blood pressure, high blood cholesterol, and stroke.

The exact cause of mitral valve prolapse is not known; however, most people are born with the condition. Mitral valve prolapse tends to run in families and is more common in people who are born with connective tissue disorders, such as Marfan syndrome.

To prevent heart valve disease caused by rheumatic fever, see your doctor if you have signs of a strep infection. Heart-healthy eating, physical activity, other heart-healthy lifestyle changes, and medicines aimed at preventing a heart attack, high blood pressure, or heart failure also may help prevent heart valve disease.