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The goal of the NHALES Study is to help scientists understand how bacteria and other factors in the environment affect people who have moderate to severe asthma.

Many women develop irregular menstrual cycles which may make it difficult to become pregnant and increase the risk of osteoporosis.

According to the Centers for Disease Control and Prevention, cigarette smoking causes more than 480,000 deaths each year in the United States, which translates to causing nearly one of every five deaths.

NINDS Clinical Director Dr. Avindra Nath meets with clinical trial participant Mr. John Michael. Dr. Nath and his research team are conducting an NIH study to better understand amyotrophic lateral sclerosis or ALS. In the video, Mr. Michael shares his experience as a trial participant while Dr. Nath discusses his research. “Ever since being diagnosed in January of ’14, I kind of made it a mission of mine to find out as much as I can, what’s available out there as treatments, trials, and just my way of giving back, whether it helps me directly or somebody who comes after me,” Mr. Michael says.

The Environmental Polymorphisms Registry (EPR) is a long-term initiative to collect approximately 20,000 DNA samples from individuals.

This study intends to investigate the genetic and environmental risk factors involved in the development of myositis, an autoimmune muscle disease that causes chronic muscle weakness.

The gene p53 suppresses cancer and inflammation in the body, and NIEHS investigators speculate that changes in p53 lead to changes in inflammation and the ability to repair DNA damage.

Researchers are interested in developing a registry protocol to obtain biologic and environmental samples anonymously from adult volunteers for use in laboratory tests and studies.

The goal of this study is to examine the genetic and environmental risk factors in the development of autoimmune diseases in twins and same-sex siblings, when one has an autoimmune disease and the other does not.

This study will evaluate subjects with adult- and childhood-onset myositis to learn more about their causes and the immune system changes and medical problems associated with them.